SCHEMBL11443003

SCHEMBL11443003

Cc1ccccc1C(Cl)=Nc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 3/20 0.43
NOS3 P29474 2/20 0.43
HTR3E A5X5Y0 2/20 0.40
HTR3B O95264 2/20 0.40
HTR3A P46098 2/20 0.40
HTR3D Q70Z44 2/20 0.40
HTR3C Q8WXA8 2/20 0.40
SLC22A2 O15244 1/20 0.40
SLC22A1 O15245 1/20 0.40
SLC22A3 O75751 1/20 0.40
PLAU P00749 1/20 0.40
HPGD P15428 2/20 0.39
CYP2D6 P10635 1/20 0.39
HIF1A Q16665 1/20 0.39
CRHR1 P34998 1/20 0.38
ERCC5 P28715 1/20 0.38
FEN1 P39748 1/20 0.38
MAPT P10636 1/20 0.38
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11443002 1.00 NOS1 (0.43) NOS1NOS3HTR3EHTR3BHTR3A
SCHEMBL28147978 0.78 KDM4E (0.45) NOS1NOS3HTR3EHTR3BHTR3A
SCHEMBL406589 0.77 TSHR (0.39) HPGDERCC5FEN1NPC1RAB9A
SCHEMBL31204265 0.77 TSHR (0.39) HPGDERCC5FEN1NPC1RAB9A
SCHEMBL406588 0.77 TSHR (0.39) HPGDERCC5FEN1NPC1RAB9A
SCHEMBL14904944 0.77 NOS1 (0.41) NOS1NOS3HTR3EHTR3BHTR3A
SCHEMBL28296397 0.76 CYP2D6 (0.56) NOS1NOS3HTR3EHTR3BHTR3A
SCHEMBL5201137 0.75 MAOA (0.39) HPGDERCC5FEN1NPC1RAB9A
SCHEMBL5201132 0.75 MAOA (0.39) HPGDERCC5FEN1NPC1RAB9A
Hydrochloric Acid SCHEMBL11770197 0.74 CYP2D6 (0.55) NOS1NOS3HTR3EHTR3BHTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-55019256-A None JP disclosed
JP-S5519256-A PROTECTANT OF RICE PLANT AGAINST SHEATH BLIGHT HOKKO CHEM IND CO LTD 1980-02-09 JP disclosed