Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144608 | 1.00 | NPSR1 (0.39) | NPSR1GLO1ALDH1A1GAAMEN1 | |
| Trichloroethylene SCHEMBL28533493 | 0.92 | ALDH1A1 (0.34) | NPSR1GLO1ALDH1A1GAAMEN1 | |
| Hydrochloric Acid SCHEMBL28148061 | 0.84 | NPSR1 (0.46) | NPSR1GLO1ALDH1A1GAAMEN1 | |
| SCHEMBL1213472 | 0.83 | RECQL (0.37) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1213476 | 0.83 | RECQL (0.37) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL21986966 | 0.81 | GLO1 (0.56) | NPSR1GLO1ALDH1A1GAAMEN1 | |
| SCHEMBL27834732 | 0.80 | NPSR1 (0.40) | NPSR1GLO1ALDH1A1GAAMEN1 | |
| SCHEMBL21974583 | 0.79 | NPSR1 (0.39) | NPSR1GLO1ALDH1A1GAAMEN1 | |
| SCHEMBL16692406 | 0.77 | NPSR1 (0.48) | NPSR1GLO1ALDH1A1GAAMEN1 | |
| SCHEMBL364547 | 0.75 | NPSR1 (0.47) | NPSR1GLO1ALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592578-B2 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2013-11-26 | — | — | US | disclosed |
| US-8586750-B2 | Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters | BASF SE (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20130041147-A1 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2013-02-14 | — | — | US | disclosed |
| US-8314233-B2 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2012-11-20 | — | — | US | disclosed |
| US-20110046371-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20110040096-A1 | Method for the Production of Halogen-Substituted 2-(aminomethylidene)-3-oxobutyric Acid Esters | BASF SE (DE) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130041147-A1 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | FFAR3, CBR3, NMBR | NPSR1 191/4885GLO1 2741/4885ALDH1A1 1418/4885 |
| US-20110046371-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | FFAR3, CBR3, NMBR | NPSR1 191/4885GLO1 2741/4885ALDH1A1 1418/4885 |
| US-20110040096-A1 | Method for the Production of Halogen-Substituted 2-(aminomethylidene)-3-oxobutyric Acid Esters | AADAC, CBR3, AOC3 | NPSR1 2619/4885GLO1 996/4885ALDH1A1 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.