Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144905 | 1.00 | NFE2L2 (0.50) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL6772335 | 0.98 | NFE2L2 (0.52) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL6772333 | 0.98 | NFE2L2 (0.52) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL1219859 | 0.82 | RECQL (0.57) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL1219862 | 0.82 | RECQL (0.57) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL7916953 | 0.82 | NFE2L2 (0.44) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL2647676 | 0.82 | NFE2L2 (0.44) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL2647678 | 0.82 | NFE2L2 (0.44) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL1144885 | 0.78 | HCAR2 (0.48) | HCAR2ALDH1A1MAPTUSP2LMNA | |
| SCHEMBL1144886 | 0.78 | HCAR2 (0.48) | HCAR2ALDH1A1MAPTUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104016920-B | A kind of co-production of fluorine-containing methylpyrazole compounds | 联化科技股份有限公司 | 2016-08-24 | — | — | CN | disclosed |
| EP-2300417-B1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2015-07-22 | — | — | EP | disclosed |
| CN-104016920-A | Co-production method of fluorine-containing methylpyrazole compounds | LIANHE CHEMICAL TECHNOLOGY SHANGHAI CO LTD | 2014-09-03 | — | — | CN | disclosed |
| CN-102015622-B | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE | 2014-07-16 | — | — | CN | disclosed |
| US-8592578-B2 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2013-11-26 | — | — | US | disclosed |
| US-8586750-B2 | Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters | BASF SE (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20130041147-A1 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2013-02-14 | — | — | US | disclosed |
| US-8314233-B2 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2012-11-20 | — | — | US | disclosed |
| EP-2297111-B1 | METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS | BASF SE (DE) | 2012-06-20 | — | — | EP | disclosed |
| EP-2300417-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2011-03-30 | — | — | EP | disclosed |
| EP-2297111-A2 | METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS | BASF SE (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-20110046371-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20110040096-A1 | Method for the Production of Halogen-Substituted 2-(aminomethylidene)-3-oxobutyric Acid Esters | BASF SE (DE) | 2011-02-17 | — | — | US | disclosed |
| WO-2009133178-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133179-A2 | METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS | BASF SE (DE) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130041147-A1 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | FFAR3, CBR3, NMBR | NFE2L2 1443/4885HCAR2 65/4885KEAP1 4059/4885 |
| US-20110046371-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | FFAR3, CBR3, NMBR | NFE2L2 1443/4885HCAR2 65/4885KEAP1 4059/4885 |
| US-20110040096-A1 | Method for the Production of Halogen-Substituted 2-(aminomethylidene)-3-oxobutyric Acid Esters | AADAC, CBR3, AOC3 | NFE2L2 1621/4885HCAR2 151/4885KEAP1 3205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.