Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | USP2 | O75604 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1219859 | 1.00 | RECQL (0.57) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL6772333 | 0.84 | NFE2L2 (0.52) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL6772335 | 0.84 | NFE2L2 (0.52) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL1144905 | 0.82 | NFE2L2 (0.50) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL1144907 | 0.82 | NFE2L2 (0.50) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL23883080 | 0.80 | ALDH1A1 (0.55) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL3310731 | 0.80 | ALDH1A1 (0.55) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL17010360 | 0.78 | MAPT (0.49) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL6454724 | 0.77 | RECQL (0.49) | RECQLALDH1A1MAPTUSP2ALOX12 | |
| SCHEMBL2647676 | 0.77 | NFE2L2 (0.44) | RECQLALDH1A1MAPTUSP2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362874-B | Preparation method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid | 徐州圣元化工有限公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-111362874-A | Preparation method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid | 徐州圣元化工有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-105969022-A | Core-shell nanoparticles | 帝斯曼知识产权资产管理有限公司 | 2016-09-28 | — | — | CN | disclosed |
| EP-2300417-B1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2015-07-22 | — | — | EP | disclosed |
| US-8592578-B2 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2013-11-26 | — | — | US | disclosed |
| US-20130041147-A1 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2013-02-14 | — | — | US | disclosed |
| US-8314233-B2 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2012-11-20 | — | — | US | disclosed |
| CN-102471592-A | Electrically conductive polymer composition and method for producing same | SOKEN KAGAKU KK | 2012-05-23 | — | — | CN | disclosed |
| CN-102471593-A | Composition for solid electrolyte and solar cell using same | SOKEN KAGAKU KK | 2012-05-23 | — | — | CN | disclosed |
| EP-2300417-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2011-03-30 | — | — | EP | disclosed |
| US-20110046371-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2011-02-24 | — | — | US | disclosed |
| WO-2009133178-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130041147-A1 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | FFAR3, CBR3, NMBR | RECQL 4084/4885ALDH1A1 1418/4885MAPT 4661/4885 |
| US-20110046371-A1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | FFAR3, CBR3, NMBR | RECQL 4084/4885ALDH1A1 1418/4885MAPT 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.