Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 18/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 17/20 | 0.64 |
| ▸ | CHUK | O15111 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.58 |
| ▸ | CLK2 | P49760 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | ITK | Q08881 | 1/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.58 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.58 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.54 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440910 | 0.78 | ADORA1 (1.00) | ADORA1ADORA2AADORA2B | |
| SCHEMBL31060121 | 0.75 | MAP4K4 (0.57) | ADORA1ADORA2ACHUKPRKD3MAP4K4 | |
| SCHEMBL1145340 | 0.74 | MAPK8 (1.00) | ADORA1ADORA2ACHUKPRKD3MAP4K4 | |
| SCHEMBL5329331 | 0.74 | ADORA1 (0.56) | ADORA1ADORA2ACHUKPRKD3MAP4K4 | |
| SCHEMBL15840888 | 0.72 | ADORA1 (0.64) | ADORA1ADORA2AHSD17B10ADORA2BXDH | |
| SCHEMBL6445072 | 0.72 | ADORA1 (0.80) | ADORA1ADORA2AADORA2B | |
| SCHEMBL11102054 | 0.72 | ALDH1A1 (0.56) | ADORA1ADORA2ACHUKMAPK8ADORA2B | |
| SCHEMBL1145344 | 0.72 | SMN1; SMN2 (0.56) | ADORA1ADORA2AMAPK8MAPK9ADORA2B | |
| SCHEMBL19665238 | 0.72 | ADORA1 (0.69) | ADORA1ADORA2AHSD17B10ADORA2B | |
| SCHEMBL20041347 | 0.72 | ADORA1 (0.77) | ADORA1ADORA2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | disclosed |
| WO-2006083673-A2 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF C-JUN N-TERMINAL KINASES | ABBOTT LABORATORIES (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | MAPKAPK3, MAP3K3, MAPK3 | ADORA1 4786/4885ADORA2A 4663/4885CHUK 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.