Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 5/20 | 0.69 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.67 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.67 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.67 |
| ▸ | GABRP | O00591 | 1/20 | 0.67 |
| ▸ | GABRD | O14764 | 1/20 | 0.67 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.67 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355886 | 0.87 | OPRK1 (0.73) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL11855695 | 0.86 | OPRK1 (0.69) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5361417 | 0.85 | OPRK1 (0.72) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL3579580 | 0.85 | OPRK1 (0.73) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5349082 | 0.85 | TP53 (0.84) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL16777701 | 0.83 | NPSR1 (0.72) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL11576383 | 0.83 | OPRK1 (0.68) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL9040148 | 0.83 | OPRK1 (0.71) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL9039066 | 0.83 | CYP1A2 (0.75) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL11577195 | 0.83 | OPRK1 (0.65) | OPRK1NR1I2ADORA3OPRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2518 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024150170-A1 | PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2024-07-18 | — | — | WO | claimed |
| US-20240238250-A1 | METHOD OF USING PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2024-07-18 | — | — | US | claimed |
| US-10689373-B2 | 1,2-substituted cyclopentanes as orexin receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-06-23 | — | — | US | claimed |
| US-20190275048-A1 | METHOD OF TREATING INSOMNIA | ROSENBERG LEON I (US) | 2019-09-12 | — | — | US | claimed |
| US-20180282309-A1 | 1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | US | claimed |
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| US-8735383-B2 | Glycine transporter-1 inhibitors | AMGEN INC. (US) | 2014-05-27 | — | — | US | claimed |
| US-8268352-B2 | Modified release composition for highly soluble drugs | TORRENT PHARMACEUTICALS LIMITED (IN) | 2012-09-18 | — | — | US | claimed |
| US-8263125-B2 | Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients | TORRENT PHARMACEUTICALS LIMITED (IN) | 2012-09-11 | — | — | US | claimed |
| US-20120195985-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | AMGEN INC. (US) | 2012-08-02 | — | — | US | claimed |
| US-20060018934-A1 | Novel drug delivery system | TORRENT PHARMACEUTICALS LIMITED (IN) | 2006-01-26 | — | — | US | claimed |
| US-20060018933-A1 | Novel drug delivery system | TORRENT PHARMACEUTICALS LIMITED (IN) | 2006-01-26 | — | — | US | claimed |
| EP-1599199-A2 | METHODS FOR TREATING JOINT PAIN OR IMPROVING SLEEP USING AN ESTROGEN AGONIST/ANTAGONIST | Pfizer Products Inc. (US) | 2005-11-30 | — | — | EP | claimed |
| WO-2004064832-A2 | METHODS FOR TREATING JOINT PAIN OR IMPROVING SLEEP USING AN ESTROGEN AGONIST/ANTAGONIST | PFIZER PRODUCTS INC. (US) | 2004-08-05 | — | — | WO | claimed |
| US-20040152713-A1 | Methods for treating joint pain or improving sleep using an estrogen agonist/antagonist | PFIZER INC. | 2004-08-05 | — | — | US | claimed |
| JP-2000511885-A | — | — | 2000-09-12 | — | — | JP | claimed |
| EP-0900086-A4 | ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE | MERCK & CO INC (US) | 2000-01-12 | — | — | EP | claimed |
| EP-0900086-A1 | ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE | Merck & Co., Inc. (US) | 1999-03-10 | — | — | EP | claimed |
| WO-1997041879-A1 | ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE | MERCK & CO., INC. (US) | 1997-11-13 | — | — | WO | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |