Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 5/20 | 0.69 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.68 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.68 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.68 |
| ▸ | GABRP | O00591 | 1/20 | 0.68 |
| ▸ | GABRD | O14764 | 1/20 | 0.68 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.68 |
| ▸ | ALB | P02768 | 1/20 | 0.68 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.68 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.68 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355886 | 0.88 | OPRK1 (0.73) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5349082 | 0.88 | TP53 (0.84) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Pinazepam SCHEMBL29407445 | 0.87 | OPRK1 (0.69) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Pinazepam SCHEMBL155928 | 0.87 | OPRK1 (0.69) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL9039066 | 0.86 | CYP1A2 (0.75) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5361417 | 0.86 | OPRK1 (0.72) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL9040148 | 0.86 | OPRK1 (0.71) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Halazepam SCHEMBL78995 | 0.85 | OPRK1 (1.00) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5354510 | 0.85 | OPRK1 (0.69) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Fosazepam SCHEMBL114556 | 0.85 | OPRK1 (0.69) | OPRK1NR1I2ADORA3OPRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190778-A1 | 3,4-DIHYDROBENZO[1,2,3]THIADIAZINE-1,1-DIOXIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, MEDICAMENTS CONTAINING SAID DERIVATIVES AND THEIR USE | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENTARSASAG (HU) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190778-A1 | 3,4-DIHYDROBENZO[1,2,3]THIADIAZINE-1,1-DIOXIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, MEDICAMENTS CONTAINING SAID DERIVATIVES AND THEIR USE | TDO2, DHODH, DHPS | OPRK1 549/4885NR1I2 353/4885ADORA3 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.