Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.64 |
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD1 | P21728 | 4/20 | 0.51 |
| ▸ | DRD5 | P21918 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11459467 | 0.97 | HRH3 (0.60) | HRH3HRH1CYP2D6SIGMAR1HTR1A | |
| SCHEMBL11466219 | 0.94 | HRH3 (0.64) | HRH3HRH1CYP2D6SIGMAR1HTR1A | |
| SCHEMBL2567353 | 0.91 | HRH3 (0.67) | HRH3HRH1CYP2D6SIGMAR1HTR1A | |
| SCHEMBL12950793 | 0.89 | HRH3 (0.62) | HRH3HRH1CYP2D6SIGMAR1HTR1A | |
| SCHEMBL5904101 | 0.81 | SIGMAR1 (0.71) | HRH3HRH1SIGMAR1HTR1AOPRM1 | |
| SCHEMBL29438692 | 0.80 | HRH3 (0.53) | HRH3HRH1CYP2D6SIGMAR1HTR1A | |
| SCHEMBL4923590 | 0.79 | HRH3 (0.77) | HRH3HRH1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4622628 | 0.79 | SIGMAR1 (0.68) | HRH3HRH1SIGMAR1HTR1A | |
| SCHEMBL11457338 | 0.79 | DRD1 (0.60) | HRH3DRD2DRD1DRD5DRD3 | |
| SCHEMBL6071227 | 0.78 | HRH3 (1.00) | HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4233217-A | USED AS ANALGESICS, NARCOTIC ANTAGONISTS, AND ANTIHISTAMINES | PENNWALT CORPORATION (US) | 1980-11-11 | — | — | US | disclosed |
| US-4210749-A | USED AS ANALGESICS, NARCOTIC ANTAGONISTS | PENNWALT CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |