Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12950793 | 0.88 | HRH3 (0.62) | HRH3THRBDRD1DRD5SIGMAR1 | |
| SCHEMBL31534242 | 0.83 | ABCB1 (0.52) | KDM4E | |
| SCHEMBL11466219 | 0.83 | HRH3 (0.64) | HRH3DRD1DRD5SIGMAR1HRH1 | |
| SCHEMBL2567353 | 0.82 | HRH3 (0.67) | HRH3THRBDRD1DRD5SIGMAR1 | |
| SCHEMBL30068748 | 0.81 | THRB (0.46) | HRH3THRBSIGMAR1HRH1DRD3 | |
| SCHEMBL30845461 | 0.81 | DRD2 (0.47) | HRH3DRD1DRD5SIGMAR1PRMT5 | |
| SCHEMBL11455692 | 0.80 | HRH3 (0.64) | HRH3DRD1DRD5SIGMAR1HRH1 | |
| SCHEMBL11459467 | 0.80 | HRH3 (0.60) | HRH3DRD1DRD5SIGMAR1HRH1 | |
| SCHEMBL12719849 | 0.80 | PKM (0.55) | HRH3THRBCYP2D6 | |
| Hydrochloric Acid SCHEMBL1626954 | 0.79 | PKM (0.54) | HRH3THRBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114195764-A | Compound as thyroid hormone beta receptor agonist and application thereof | 广东东阳光药业有限公司 | 2022-03-18 | — | — | CN | disclosed |