Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409063 | 0.98 | HTR2C (0.35) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL118973 | 0.97 | HTR2C (0.34) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL27986246 | 0.97 | HTR2C (0.34) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| Iodide SCHEMBL11457678 | 0.67 | SLC18A3 (0.37) | — | |
| Iodide SCHEMBL22031617 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL6830548 | 0.63 | SLC18A3 (0.37) | HIF1A | |
| Hydrochloric Acid SCHEMBL22031619 | 0.62 | — | — | |
| SCHEMBL4907271 | 0.62 | ORAI1 (0.40) | HTR2CHTR2ASLC6A2SLC6A4MEN1 | |
| SCHEMBL8331771 | 0.61 | — | — | |
| SCHEMBL5281905 | 0.60 | APOBEC3A (0.37) | HTR2AHTR2BMEN1POLBAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4229462-A | N-ARYL-N'-(2-IMIDAZOLIDINYLIDENE)UREA | MCNEILAB, INC. (US) | 1980-10-21 | — | — | US | disclosed |