Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.33 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.33 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.33 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.33 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.33 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.33 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.33 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.33 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11457678 | 0.96 | SLC18A3 (0.37) | SLC18A3SIGMAR1TAAR1KDM1AMAOB | |
| SCHEMBL4428525 | 0.68 | SLC6A2 (0.38) | SLC18A3SIGMAR1TAAR1KDM1AMAOB | |
| SCHEMBL9370820 | 0.68 | CHRM2 (0.47) | — | |
| SCHEMBL16226181 | 0.68 | TSHR (0.37) | SLC18A3TAAR1KDM1AMAOBMAOA | |
| Hydrochloric Acid SCHEMBL118973 | 0.67 | HTR2C (0.34) | — | |
| SCHEMBL6424367 | 0.66 | ALDH1A1 (0.35) | KDM4EHPGDTDP1ALDH1A1 | |
| SCHEMBL409063 | 0.64 | HTR2C (0.35) | — | |
| Hydrochloric Acid SCHEMBL22031619 | 0.63 | — | — | |
| SCHEMBL14066566 | 0.63 | SLC18A3 (0.60) | SLC18A3SIGMAR1TAAR1DRD2HPGD | |
| Hydrochloric Acid SCHEMBL27986246 | 0.63 | HTR2C (0.34) | TAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737547-B1 | Compositions containing and methods of using N-acyl-1H-aminoindenes | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2004-05-18 | — | — | US | disclosed |
| WO-2000038673-A1 | COMPOSITIONS CONTAINING AND METHODS OF USING N-ACYL-1H-AMINOINDENES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2000-07-06 | — | — | WO | disclosed |