SCHEMBL11458656

SCHEMBL11458656

NC(=O)/C=C/C=C\c1ccc2c(c1)OCO2

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.76
CYP1A2 P05177 2/20 0.76
HDAC6 Q9UBN7 2/20 0.70
GABRA1 P14867 5/20 0.64
GABRB2 P47870 5/20 0.64
TRPV1 Q8NER1 4/20 0.64
CYP3A4 P08684 3/20 0.64
MAOB P27338 2/20 0.64
KDM4E B2RXH2 2/20 0.64
ALDH1A1 P00352 2/20 0.64
HPGD P15428 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
NPC1 O15118 1/20 0.64
CTSD P07339 1/20 0.64
ABCB1 P08183 1/20 0.64
ALOX5 P09917 1/20 0.64
MAOA P21397 1/20 0.64
MAPK1 P28482 1/20 0.64
RAB9A P51151 1/20 0.64
DHODH Q02127 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11441141 1.00 HSD17B10 (0.76) HSD17B10CYP1A2HDAC6GABRA1GABRB2
SCHEMBL28583726 1.00 HSD17B10 (0.76) HSD17B10CYP1A2HDAC6GABRA1GABRB2
SCHEMBL1344559 1.00 HSD17B10 (0.76) HSD17B10CYP1A2HDAC6GABRA1GABRB2
Fumaric Acid SCHEMBL635750 0.94 HSD17B10 (0.82) HSD17B10CYP1A2HDAC6GABRA1GABRB2
Maleic Acid SCHEMBL635748 0.94 HSD17B10 (0.82) HSD17B10CYP1A2HDAC6GABRA1GABRB2
SCHEMBL196821 0.89 KDM4E (0.66) HSD17B10CYP1A2HDAC6TRPV1CYP3A4
SCHEMBL196822 0.89 KDM4E (0.66) HSD17B10CYP1A2HDAC6TRPV1CYP3A4
SCHEMBL25423911 0.88 HSD17B10 (0.72) HSD17B10CYP1A2HDAC6GABRA1GABRB2
Piperic Acid SCHEMBL447578 0.86 HSD17B10 (1.00) HSD17B10CYP1A2HDAC6GABRA1GABRB2
Piperic Acid SCHEMBL11460093 0.86 HSD17B10 (1.00) HSD17B10CYP1A2HDAC6GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0002735-B1 PROCESS FOR THE PREPARATION OF PIPERONYLIDENECROTON AMIDES HAARMANN & REIMER GMBH (DE) 1980-12-10 EP claimed
EP-0002734-B1 PROCESS FOR THE PREPARATION OF PIPERONYLIDENECROTON AMIDES HAARMANN & REIMER GMBH (DE) 1980-09-17 EP claimed
US-4209445-A FROM PIPERONAL AND A CROTONIC AMIDE IN PRESENCE OF QUATERNARY AMMONIUM OR PHOSPHONIUM HYDROXIDE OR CROWN ETHER METAL COMPLEX HAARMAN & REIMER GMBH (DE) 1980-06-24 US claimed
US-4209446-A FROM PIPERONAL AND A CROTONIC AMIDE IN PRESENCE OF ALKALI METAL HYDROXIDE AND DIPOLAR APROTIC DILUENT HAARMAN & REIMER GMBH (DE) 1980-06-24 US claimed
US-4209445-A FROM PIPERONAL AND A CROTONIC AMIDE IN PRESENCE OF QUATERNARY AMMONIUM OR PHOSPHONIUM HYDROXIDE OR CROWN ETHER METAL COMPLEX HAARMAN & REIMER GMBH (DE) 1980-06-24 US disclosed
US-4209446-A FROM PIPERONAL AND A CROTONIC AMIDE IN PRESENCE OF ALKALI METAL HYDROXIDE AND DIPOLAR APROTIC DILUENT HAARMAN & REIMER GMBH (DE) 1980-06-24 US disclosed
US-4209445-A FROM PIPERONAL AND A CROTONIC AMIDE IN PRESENCE OF QUATERNARY AMMONIUM OR PHOSPHONIUM HYDROXIDE OR CROWN ETHER METAL COMPLEX HAARMAN & REIMER GMBH (DE) 1980-06-24 US disclosed
US-4209446-A FROM PIPERONAL AND A CROTONIC AMIDE IN PRESENCE OF ALKALI METAL HYDROXIDE AND DIPOLAR APROTIC DILUENT HAARMAN & REIMER GMBH (DE) 1980-06-24 US disclosed
US-4209446-A FROM PIPERONAL AND A CROTONIC AMIDE IN PRESENCE OF ALKALI METAL HYDROXIDE AND DIPOLAR APROTIC DILUENT HAARMAN & REIMER GMBH (DE) 1980-06-24 US disclosed