SCHEMBL11458982

SCHEMBL11458982

Clc1[c]ccc(-n2nc3ccccc3n2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.50
HPGD P15428 6/20 0.50
KMT2A Q03164 7/20 0.41
ALDH1A1 P00352 7/20 0.41
MEN1 O00255 6/20 0.41
SMN1; SMN2 Q16637 5/20 0.41
MAPT P10636 4/20 0.41
LMNA P02545 2/20 0.41
POLB P06746 1/20 0.41
BLM P54132 1/20 0.41
CASP9 P55211 1/20 0.41
CASP6 P55212 1/20 0.41
CASP8 Q14790 1/20 0.41
HTT P42858 2/20 0.41
NPC1 O15118 10/20 0.40
RAB9A P51151 9/20 0.40
STAT1 P42224 1/20 0.40
ATM Q13315 3/20 0.38
NPSR1 Q6W5P4 1/20 0.34
TP53 P04637 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11460366 0.84 NPC1 (0.49) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL11466055 0.82 KDM4E (0.56) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL11476051 0.80 KDM4E (0.48) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL11468173 0.78 HTT (0.46) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL11458090 0.77 KDM4E (0.50) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL11790710 0.76 HTT (0.51) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL1428276 0.74 KDM4E (0.67) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL18593568 0.73 KDM4E (0.73) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL3228579 0.73 KDM4E (0.59) KDM4EHPGDKMT2AALDH1A1MEN1
SCHEMBL11477561 0.73 KDM4E (0.41) KDM4EHPGDKMT2AALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4235999-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4187229-A Bis-benzotriazole compounds EASTMAN KODAK COMPANY (US) 1980-02-05 US disclosed
US-4159270-A Bichromophoric benzotriazole-styrene ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-06-26 US disclosed
US-4085089-A Benzotriazole ultraviolet stabilizing compounds and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-04-18 US disclosed
US-4073745-A Multichromophoric benzotriazole ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-02-14 US disclosed
US-4070337-A Bichromophoric benzotriazole-styrene ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4070339-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed
US-3981884-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-09-21 US disclosed
US-3981822-A HETEROCYCLIC COMPOUNDS EASTMAN KODAK COMPANY (US) 1976-09-21 US disclosed