SCHEMBL11460366

SCHEMBL11460366

Clc1[c]ccc(-n2nc3ccc(Cl)cc3n2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 10/20 0.49
RAB9A P51151 8/20 0.49
MAPT P10636 8/20 0.49
KDM4E B2RXH2 6/20 0.49
ATM Q13315 3/20 0.49
MEN1 O00255 10/20 0.40
KMT2A Q03164 10/20 0.40
RXFP1 Q9HBX9 1/20 0.37
ALDH1A1 P00352 4/20 0.37
STAT1 P42224 1/20 0.37
POLB P06746 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
F7 P08709 1/20 0.35
F3 P13726 1/20 0.35
DYRK1A Q13627 1/20 0.35
HPGD P15428 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TP53 P04637 2/20 0.35
HSD17B10 Q99714 2/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11459888 0.86 NPC1 (0.45) NPC1RAB9AMAPTKDM4EATM
SCHEMBL11458982 0.84 KDM4E (0.50) NPC1RAB9AMAPTKDM4EATM
SCHEMBL11459783 0.84 NPC1 (0.53) NPC1RAB9AMAPTKDM4EATM
SCHEMBL11332544 0.83 NPC1 (0.56) NPC1RAB9AMAPTKDM4EATM
SCHEMBL11477561 0.81 KDM4E (0.41) NPC1RAB9AMAPTKDM4EATM
SCHEMBL11468173 0.80 HTT (0.46) NPC1RAB9AMAPTKDM4EATM
SCHEMBL11476134 0.73 NPC1 (0.49) NPC1RAB9AMAPTKDM4EATM
SCHEMBL11756589 0.73 NPC1 (0.39) NPC1RAB9AMAPTKDM4EATM
SCHEMBL3040313 0.72 NPC1 (0.81) NPC1RAB9AMAPTKDM4EATM
SCHEMBL3783238 0.72 MAPT (0.60) NPC1RAB9AMAPTKDM4EATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4235999-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4187229-A Bis-benzotriazole compounds EASTMAN KODAK COMPANY (US) 1980-02-05 US disclosed
US-4159270-A Bichromophoric benzotriazole-styrene ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-06-26 US disclosed
US-4085089-A Benzotriazole ultraviolet stabilizing compounds and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-04-18 US disclosed
US-4073745-A Multichromophoric benzotriazole ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-02-14 US disclosed
US-4070337-A Bichromophoric benzotriazole-styrene ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4070339-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed
US-3981822-A HETEROCYCLIC COMPOUNDS EASTMAN KODAK COMPANY (US) 1976-09-21 US disclosed