SCHEMBL11468173

SCHEMBL11468173

COc1ccc2nn(-c3cc[c]c(Cl)c3)nc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.46
MEN1 O00255 7/20 0.45
KMT2A Q03164 7/20 0.45
NPC1 O15118 9/20 0.42
RAB9A P51151 7/20 0.42
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
MAPT P10636 11/20 0.39
KDM4E B2RXH2 4/20 0.39
LMNA P02545 2/20 0.39
HPGD P15428 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ATM Q13315 2/20 0.39
ALDH1A1 P00352 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
POLB P06746 1/20 0.38
NQO2 P16083 1/20 0.38
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11458991 0.87 HTT (0.50) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL11466056 0.86 HTT (0.46) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL11339079 0.82 HTT (0.56) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL11460366 0.80 NPC1 (0.49) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL11458011 0.80 HTT (0.48) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL11458982 0.78 KDM4E (0.50) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL11458992 0.75 HTT (0.50) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL11755580 0.74 HTT (0.40) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL11135295 0.73 HTT (0.60) HTTMEN1KMT2ANPC1RAB9A
SCHEMBL3039434 0.73 NPC1 (0.62) HTTMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4235999-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4187229-A Bis-benzotriazole compounds EASTMAN KODAK COMPANY (US) 1980-02-05 US disclosed
US-4159270-A Bichromophoric benzotriazole-styrene ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-06-26 US disclosed
US-4085089-A Benzotriazole ultraviolet stabilizing compounds and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-04-18 US disclosed
US-4073745-A Multichromophoric benzotriazole ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-02-14 US disclosed
US-4070337-A Bichromophoric benzotriazole-styrene ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4070339-A Bichromophoric benzotriazole-styrene ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-01-24 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed
US-3981822-A HETEROCYCLIC COMPOUNDS EASTMAN KODAK COMPANY (US) 1976-09-21 US disclosed
US-3981884-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-09-21 US disclosed