Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 8/20 | 0.44 |
| ▸ | HTR2C | P28335 | 8/20 | 0.44 |
| ▸ | HTR2B | P41595 | 8/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198150 | 0.82 | DRD2 (0.55) | DRD2DRD4DRD3HTR1APNMT | |
| SCHEMBL9354984 | 0.80 | DRD2 (0.74) | DRD2DRD4DRD3HTR1ADRD1 | |
| SCHEMBL20910190 | 0.78 | DRD2 (0.47) | DRD2DRD4DRD3HTR2AHTR2C | |
| SCHEMBL24242574 | 0.77 | SLC6A4 (0.47) | HTR2AHTR2CHTR2BHTR1APNMT | |
| SCHEMBL14346890 | 0.77 | SLC6A4 (0.47) | HTR2AHTR2CHTR2BHTR1APNMT | |
| SCHEMBL3466615 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3HTR7DRD1 | |
| SCHEMBL22547374 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3HTR2AHTR2C | |
| SCHEMBL3468194 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3HTR7DRD1 | |
| SCHEMBL1640115 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3HTR7DRD1 | |
| SCHEMBL29507943 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3HTR7DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4192888-A | Pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase | SMITHKLINE CORPORATION (US) | 1980-03-11 | — | — | US | disclosed |