Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | HTR2B | P41595 | 6/20 | 0.44 |
| ▸ | HTR2A | P28223 | 5/20 | 0.44 |
| ▸ | PNMT | P11086 | 4/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14346890 | 1.00 | SLC6A4 (0.47) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL13799412 | 0.84 | HTR2A (0.46) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL14525564 | 0.84 | HTR2A (0.46) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL14525576 | 0.81 | HTR2C (0.38) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL293771 | 0.77 | CA1 (0.50) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL24387477 | 0.77 | PNMT (0.44) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL24051774 | 0.77 | CA1 (0.50) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL24051597 | 0.77 | CA1 (0.50) | SLC6A4HTR2CHTR2BHTR2APNMT | |
| SCHEMBL13799411 | 0.77 | DRD2 (0.50) | HTR1A | |
| SCHEMBL12618257 | 0.77 | PNMT (0.41) | SLC6A4HTR2CHTR2BHTR2APNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11242337-B2 | Compounds useful for treating gastrointestinal tract disorders | ARDELYX, INC. (US) | 2022-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242337-B2 | Compounds useful for treating gastrointestinal tract disorders | SLC10A2, FABP2, SLC10A1 | SLC6A4 244/4885HTR2C 762/4885HTR2B 1756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.