SCHEMBL1146385

SCHEMBL1146385

CCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(OCCN(C)C)nc3)c2n1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.74
IL6 P05231 10/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30323751 1.00 TLR7 (0.74) TLR7IL6
SCHEMBL20756317 0.94 TLR7 (0.73) TLR7IL6
SCHEMBL1146668 0.91 TLR7 (0.72) TLR7IL6
SCHEMBL27249516 0.85 TLR7 (0.85) TLR7IL6
SCHEMBL30747804 0.85 TLR7 (0.85) TLR7IL6
SCHEMBL27249641 0.85 TLR7 (1.00) TLR7IL6
SCHEMBL27249640 0.85 TLR7 (1.00) TLR7IL6
SCHEMBL30747687 0.85 TLR7 (1.00) TLR7IL6
SCHEMBL30747764 0.85 TLR7 (1.00) TLR7IL6
SCHEMBL1145803 0.84 TLR7 (0.68) TLR7IL6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170022-A1 COMBINATION DRUG INCLUDING TLR7 AGONIST Sumitomo Pharma Co., Ltd. (JP) 2021-06-10 US claimed
EP-3730152-A1 COMBINATION DRUG INCLUDING TLR7 AGONIST Sumitomo Dainippon Pharma Co., Ltd. (JP) 2020-10-28 EP claimed
CN-111757755-A Combination comprising a TLR7 agonist 大日本住友制药株式会社 2020-10-09 CN claimed
US-20110028715-A1 NOVEL ADENINE COMPOUND DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2011-02-03 US claimed
US-20100093998-A1 NOVEL ADENINE COMPOUND DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2010-04-15 US claimed
EP-2133353-A1 NOVEL ADENINE COMPOUND Dainippon Sumitomo Pharma Co., Ltd. (JP) 2009-12-16 EP claimed
US-12226480-B2 Combination drug including TLR7 agonist Sumitomo Pharma Co., Ltd. (JP) 2025-02-18 US disclosed
US-12059462-B2 Composition containing influenza vaccine JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES (JP) 2024-08-13 US disclosed
CN-116115765-A Combination comprising TLR7 agonists 住友制药株式会社 2023-05-16 CN disclosed
US-20210353737-A1 COMPOSITION CONTAINING INFLUENZA VACCINE Sumitomo Pharma Co., Ltd. (JP) 2021-11-18 US disclosed
US-20210170022-A1 COMBINATION DRUG INCLUDING TLR7 AGONIST Sumitomo Pharma Co., Ltd. (JP) 2021-06-10 US disclosed
EP-3827842-A1 COMPOSITION CONTAINING INFLUENZA VACCINE JAPAN as represented by DIRECTOR GENERAL of National Institute of Infectious Diseases (JP) 2021-06-02 EP disclosed
CN-112839673-A Compositions comprising influenza vaccines 日本国立感染症研究所所长代表之日本国 2021-05-25 CN disclosed
US-20110028715-A1 NOVEL ADENINE COMPOUND DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2011-02-03 US disclosed
US-20110028715-A1 NOVEL ADENINE COMPOUND DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2011-02-03 US disclosed
US-20100093998-A1 NOVEL ADENINE COMPOUND DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2010-04-15 US disclosed
US-20100093998-A1 NOVEL ADENINE COMPOUND DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2010-04-15 US disclosed
US-20100093998-A1 NOVEL ADENINE COMPOUND DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2010-04-15 US disclosed
EP-2133353-A1 NOVEL ADENINE COMPOUND Dainippon Sumitomo Pharma Co., Ltd. (JP) 2009-12-16 EP disclosed
EP-2133353-A1 NOVEL ADENINE COMPOUND Dainippon Sumitomo Pharma Co., Ltd. (JP) 2009-12-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110028715-A1 NOVEL ADENINE COMPOUND NR0B2, NR0B1, BRD7 TLR7 4/4885IL6 3123/4885
US-12226480-B2 Combination drug including TLR7 agonist TLR7, TLR9, CD274 TLR7 1/4885IL6 829/4885
US-20210170022-A1 COMBINATION DRUG INCLUDING TLR7 AGONIST TLR7, TLR9, CD274 TLR7 1/4885IL6 829/4885
US-12059462-B2 Composition containing influenza vaccine LY96, CD209, PLA2G12B TLR7 15/4885IL6 2123/4885
US-20210353737-A1 COMPOSITION CONTAINING INFLUENZA VACCINE LY96, CD209, PLA2G12B TLR7 15/4885IL6 2123/4885
US-20100093998-A1 NOVEL ADENINE COMPOUND NR0B2, NR0B1, BRD7 TLR7 4/4885IL6 3201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.