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Sugi Predict / Targets / PLA2G12B

PLA2G12B

Group XIIB secretory phospholipase A2-like pr · Q9BX93 · PLA2G12B on Sugi Atlas →

1,380 patent compounds predicted against PLA2G12B, 969 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Varespladib Varespladib (SCHEMBL26726) 1.00 1/20
SCHEMBL7682372 SCHEMBL7682372 0.87 1/20
SCHEMBL818585 SCHEMBL818585 0.85 1/20
SCHEMBL5150404 SCHEMBL5150404 0.84 1/20
Varespladib Methyl Varespladib Methyl (SCHEMBL25678) 0.83 1/20
Varespladib Varespladib (SCHEMBL1232548) 0.83 1/20
SCHEMBL5710595 SCHEMBL5710595 0.82 1/20
SCHEMBL5710700 SCHEMBL5710700 0.82 1/20
SCHEMBL5710708 SCHEMBL5710708 0.82 1/20
SCHEMBL6812616 SCHEMBL6812616 0.82 1/20
SCHEMBL5710565 SCHEMBL5710565 0.80 1/20
SCHEMBL5710591 SCHEMBL5710591 0.80 1/20
SCHEMBL7171270 SCHEMBL7171270 0.80 1/20
SCHEMBL5710584 SCHEMBL5710584 0.79 1/20
SCHEMBL7962736 SCHEMBL7962736 0.79 1/20
SCHEMBL818498 SCHEMBL818498 0.79 1/20
SCHEMBL1514327 SCHEMBL1514327 0.79 1/20
SCHEMBL7168376 SCHEMBL7168376 0.78 1/20
SCHEMBL5153686 SCHEMBL5153686 0.78 1/20
SCHEMBL5710556 SCHEMBL5710556 0.78 1/20

Clinical trials — most relevant to PLA2G12B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL) PHASE4COMPLETED
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis PHASE3COMPLETED
Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy PHASE3COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes PHASE3UNKNOWN
European Celecoxib Trial in Primary Breast Cancer PHASE3COMPLETED
Obinutuzumab Induced Decreases of PLA2R Antibodies in Membranous Nephropathy: a Pilot Study PHASE2/PHASE3RECRUITING
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM PHASE3COMPLETED
Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy PHASE3UNKNOWN
Trial to Assess Safety and Efficacy of MOR202 in Anti-PLA2R + Membranous Nephropathy (aMN) PHASE1/PHASE2COMPLETED
Assessment of Coronary Plaque Composition PHASE1COMPLETED
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis nanUNKNOWN
Role of PLA2G1B During HIV Infection nanUNKNOWN
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes nanCOMPLETED
Effect of B-cell Depleting Therapies on PLA2R-specific B Cells in Patients With Membranous Nephropathy nanCOMPLETED
Analysis of T- and B-Cell Subpopulations in Membranous Nephropathy nanCOMPLETED
An Outcome Analysis of Primary Membranous Nephropathy nanRECRUITING
Clinical Trial of Anti-PLA2R-IgG Detection Kit (Time-resolved Fluorescence Immunoassay) nanCOMPLETED
Mucomyst for Hepatitis C nanSUSPENDED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Immunopathological Analysis in a French National Cohort of Membranous Nephropathy nanRECRUITING
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke nanCOMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis. nanCOMPLETED
Role of Anti-mouse PLA2R1 ELISA in Membranous Nephropathy nanCOMPLETED
Omics of Rituximab-resistance nanNOT_YET_RECRUITING
Lp-PLA2 and Coronary Atherosclerosis in Humans nanCOMPLETED
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations nanCOMPLETED
Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant nanCOMPLETED
Surfactant Derived Protocol in Heart Failure nanCOMPLETED
Positron Emission Tomography (PET) to Study Brain Signaling nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a PLA2G12B binder may also engage these)

ProteinNameSimilarity
Q99P27 — 1.000 Q99P27 →
B1AKI9 — 0.966 B1AKI9 →
Q8BJQ9 — 0.965 Q8BJQ9 →
Q8QFV1 — 0.963 Q8QFV1 →
O75129 — 0.962 O75129 →
P01185 — 0.962 P01185 →
Q9CWQ3 — 0.962 Q9CWQ3 →
Q8C1F4 — 0.961 Q8C1F4 →
Q5EGE1 — 0.960 Q5EGE1 →
E1BBQ2 — 0.960 E1BBQ2 →
ATP6AP1 V-type proton ATPase subunit S1 0.959 landscape →
D4A6L0 — 0.959 D4A6L0 →
CSGALNACT1 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.959 landscape →
Q8N6G5 — 0.959 Q8N6G5 →
Q6L9W6 — 0.959 Q6L9W6 →
Q6DVA0 — 0.959 Q6DVA0 →
Q8R143 — 0.958 Q8R143 →
Q9EPI0 — 0.958 Q9EPI0 →
ABHD16A Phosphatidylserine lipase ABHD16A 0.958 landscape →
O88824 — 0.958 O88824 →
P51654 — 0.957 P51654 →
A0JPH4 — 0.957 A0JPH4 →
Q5QQ49 — 0.957 Q5QQ49 →
Q5R2I8 — 0.957 Q5R2I8 →
Q99ML4 — 0.957 Q99ML4 →
Q91XQ5 — 0.957 Q91XQ5 →
Q8NFZ0 — 0.957 Q8NFZ0 →
A8WCC4 — 0.957 A8WCC4 →
O14525 — 0.956 O14525 →
O70367 — 0.956 O70367 →