SCHEMBL11465239

SCHEMBL11465239

BrCC1(c2cccc(Br)c2)OCCO1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.39
CHRNG P07510 1/20 0.39
CHRNB1 P11230 1/20 0.39
CHRNB2 P17787 1/20 0.39
SLC6A2 P23975 1/20 0.39
CHRNB4 P30926 1/20 0.39
SLC6A4 P31645 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA4 P43681 1/20 0.39
SLC6A3 Q01959 1/20 0.39
CHRND Q07001 1/20 0.39
UTS2R Q9UKP6 1/20 0.33
HCAR3 P49019 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
MAPK1 P28482 2/20 0.33
TSHR P16473 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ALDH1A1 P00352 2/20 0.32
SIGMAR1 Q99720 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3280576 0.84 CHRNA1 (0.41) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL11541948 0.81 HTR2C (0.42) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL11544390 0.81 HTR2C (0.42) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL10852562 0.79 L3MBTL1 (0.37) SLC6A2SLC6A4SLC6A3UTS2RSMN1; SMN2
SCHEMBL169659 0.79 L3MBTL1 (0.47) SMN1; SMN2MAPK1TSHRL3MBTL1ALDH1A1
SCHEMBL9367962 0.77 KDM4E (0.37) SMN1; SMN2MAPK1TSHRL3MBTL1ALDH1A1
SCHEMBL11541125 0.77 KDM1A (0.49) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL11462587 0.76 HPGD (0.34) L3MBTL1
SCHEMBL11455590 0.74 KDM1A (0.51) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL855229 0.74 CHRNA1 (0.48) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4209447-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1980-06-24 US disclosed
US-4139540-A FUNGICIDE, BACTERICIDE INTERMEDIATE JANSSEN PHARMACEUTICA N.V. (BE) 1979-02-13 US disclosed