Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170686 | 0.84 | ALDH1A1 (0.51) | CYP3A4CYP2C9CYP2C19MAPTPOLB | |
| SCHEMBL2152203 | 0.77 | GAA (0.51) | CYP3A4CYP2C9CYP2C19MAPTPOLB | |
| SCHEMBL3359904 | 0.76 | SMN1; SMN2 (0.55) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 | |
| SCHEMBL23479973 | 0.73 | CYP3A4 (0.59) | CYP3A4CYP2C9CYP2C19MAPTLMNA | |
| SCHEMBL7711892 | 0.73 | MAPT (0.86) | MAPTPOLBLMNAGAAALDH1A1 | |
| SCHEMBL5672302 | 0.72 | EPHX2 (0.56) | LMNAALDH1A1RECQLHSD17B10KMT2A | |
| SCHEMBL12745725 | 0.72 | MEN1 (0.50) | MAPTPOLBLMNAGAAALDH1A1 | |
| SCHEMBL2390346 | 0.71 | HSD11B1 (0.48) | LMNAKMT2A | |
| SCHEMBL5445415 | 0.71 | MAPT (0.81) | MAPTPOLBLMNAGAAALDH1A1 | |
| SCHEMBL15052471 | 0.71 | CYP3A4 (0.51) | CYP3A4CYP2C9CYP2C19MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4200588-A | ANTILIPEMIC AGENTS, ANTIATHEROSCLEROTIC | THE UPJOHN COMPANY (US) | 1980-04-29 | — | — | US | disclosed |
| US-4130561-A | Polycycloanilines | THE UPJOHN COMPANY (US) | 1978-12-19 | — | — | US | disclosed |
| US-4120899-A | HYPOLIPEDEMIC, ANTIATHEROSCLEROTIC | THE UPJOHN COMPANY (US) | 1978-10-17 | — | — | US | disclosed |
| US-4036977-A | HYPOLIPEDEMIC AND ANTIATHEROSCLEROTIC PROPERTIES | THE UPJOHN COMPANY (US) | 1977-07-19 | — | — | US | disclosed |