Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457403 | 0.93 | HTR1A (0.54) | HTR1AHTR7DRD4DRD2DRD3 | |
| SCHEMBL11447503 | 0.88 | HTR1A (0.51) | HTR1AHTR7DRD4DRD2DRD3 | |
| SCHEMBL11447474 | 0.88 | HTR1A (0.51) | HTR1AHTR7DRD4DRD2 | |
| Methane SCHEMBL11602997 | 0.87 | HTR1A (0.50) | HTR1AHTR7DRD4DRD2 | |
| SCHEMBL11446726 | 0.87 | HTR1A (0.53) | HTR1AHTR7DRD4DRD2DRD3 | |
| SCHEMBL11456961 | 0.85 | MAPT (0.56) | HTR1AHTR7DRD4DRD2 | |
| SCHEMBL6933580 | 0.84 | HTR1A (0.71) | HTR1AHTR7DRD4DRD2ADRA1D | |
| SCHEMBL11448262 | 0.84 | HTR1A (0.58) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL11602992 | 0.83 | HTR1A (0.49) | HTR1AHTR7DRD4DRD2 | |
| SCHEMBL11605140 | 0.83 | HTR1A (0.49) | HTR1AHTR7DRD4DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |