SCHEMBL1146579

SCHEMBL1146579

CCc1ccc(Cc2cc([C@]3(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2C#N)cc1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 0.49
SLC5A1 P13866 14/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27752477 1.00 SLC5A2 (0.49) SLC5A2SLC5A1
SCHEMBL2868799 0.92 SLC5A2 (0.46) SLC5A2SLC5A1
SCHEMBL27752475 0.92 SLC5A2 (0.44) SLC5A2SLC5A1
SCHEMBL2870944 0.92 SLC5A2 (0.44) SLC5A2SLC5A1
SCHEMBL27731958 0.91 SLC5A2 (0.43) SLC5A2SLC5A1
SCHEMBL2868241 0.91 SLC5A2 (0.50) SLC5A2SLC5A1
SCHEMBL27731940 0.91 SLC5A2 (0.43) SLC5A2SLC5A1
SCHEMBL2858072 0.91 SLC5A2 (0.43) SLC5A2SLC5A1
SCHEMBL2870959 0.91 SLC5A2 (0.43) SLC5A2SLC5A1
SCHEMBL2864708 0.90 SLC5A2 (0.40) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3939577-A1 PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE Boehringer Ingelheim International GmbH (DE) 2022-01-19 EP claimed
US-20210283156-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF BOEHRINGER INGELHEIM INT (DE) 2021-09-16 US claimed
US-20200069713-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF BOEHRINGER INGELHEIM INT (DE) 2020-03-05 US claimed
US-20170020907-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF BOEHRINGER INGELHEIM INT (DE) 2017-01-26 US claimed
US-20160158264-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF BOEHRINGER INGELHEIM INT (DE) 2016-06-09 US claimed
US-8846613-B2 Pharmaceutical combinations for the treatment of metabolic disorders BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-09-30 US claimed
EP-2698152-A1 Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivative Boehringer Ingelheim International GmbH (DE) 2014-02-19 EP claimed
US-20140038888-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-02-06 US claimed
US-20140031301-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-01-30 US claimed
US-20130303446-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-11-14 US claimed
US-20120277149-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-11-01 US claimed
US-20120196812-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-08-02 US claimed
EP-2396005-A1 SGLT-2 INHIBITOR FOR TREATING TYPE 1 DIABETES MELLITUS, TYPE 2 DIABETE MELLITUS, IMPAIRED GLUCOSE TOLERANCE OR HYPERGLYCEMIA Boehringer Ingelheim International GmbH (DE) 2011-12-21 EP claimed
US-20110195917-A1 PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATE BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-08-11 US claimed
US-20110046087-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-02-24 US claimed
US-20100249392-A1 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-09-30 US claimed
WO-2010092123-A1 SGLT-2 INHIBITOR FOR TREATING TYPE 1 DIABETES MELLITUS, TYPE 2 DIABETE MELLITUS, IMPAIRED GLUCOSE TOLERANCE OR HYPERGLYCEMIA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-08-19 WO claimed
US-7776830-B2 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-08-17 US claimed
EP-2187879-A1 PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE Boehringer Ingelheim International GmbH (DE) 2010-05-26 EP claimed
WO-2009022007-A1 PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-02-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196812-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20110195917-A1 PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATE DPP4, SLC5A1, DPP7 SLC5A2 5/4885SLC5A1 2/4885
US-20140031301-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20170020907-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20210283156-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20200069713-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20140038888-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS SLC5A1, SLC5A2, CPT1A SLC5A2 2/4885SLC5A1 1/4885
US-20160158264-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20120277149-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS SLC5A1, SLC5A2, CPT1A SLC5A2 2/4885SLC5A1 1/4885
US-20110046087-A1 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20100249392-A1 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture UGGT1, UGT1A4, SLC5A1 SLC5A2 5/4885SLC5A1 3/4885
US-20130303446-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS SLC5A1, SLC5A2, G6PC1 SLC5A2 2/4885SLC5A1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.