Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9487727 | 0.82 | MAPT (0.50) | MAPTMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL11467332 | 0.80 | MAPT (0.50) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL5068509 | 0.80 | CA1 (0.75) | CA1CA2MAPTHDAC3HDAC1 | |
| SCHEMBL11297551 | 0.80 | MAPT (0.41) | CA1CA2MAPTMEN1KMT2A | |
| SCHEMBL11297553 | 0.80 | MAPT (0.41) | CA1CA2MAPTMEN1KMT2A | |
| SCHEMBL11461243 | 0.77 | MAPT (0.59) | CA1CA2MAPTHDAC1MEN1 | |
| SCHEMBL11461242 | 0.77 | MAPT (0.59) | CA1CA2MAPTHDAC1MEN1 | |
| SCHEMBL11159031 | 0.76 | PTGER4 (0.42) | MAPTHDAC3HDAC1HDAC2MEN1 | |
| SCHEMBL27996234 | 0.74 | SMN1; SMN2 (0.73) | CA1CA2MAPTMEN1KMT2A | |
| SCHEMBL11460287 | 0.74 | MAPT (0.55) | CA1CA2MAPTHDAC1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4211783-A | Hypolipidemic and antiatherosclerotic novel 4-(aralkyl- and heteroarylalkylamino)phenyl compounds | AMERICAN CYANAMID COMPANY (US) | 1980-07-08 | — | — | US | disclosed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |