Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11394437 | 0.79 | LMNA (0.43) | PTGER4MAPTCYP1A2HPGDCYP2C9 | |
| SCHEMBL11297553 | 0.78 | MAPT (0.41) | RAB9ANPC1MAPTTP53ALDH1A1 | |
| SCHEMBL11297551 | 0.78 | MAPT (0.41) | RAB9ANPC1MAPTTP53ALDH1A1 | |
| SCHEMBL11162713 | 0.77 | RAB9A (0.59) | PTGER4RAB9ANPC1MAPTCYP1A2 | |
| SCHEMBL11467331 | 0.76 | CA1 (0.56) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL846845 | 0.75 | CA12 (0.53) | RAB9ANPC1CNR1CNR2KMT2A | |
| SCHEMBL11156911 | 0.75 | CA12 (0.53) | RAB9ANPC1CNR1CNR2KMT2A | |
| SCHEMBL11150941 | 0.73 | CA12 (0.45) | PTGER4RAB9AMAPTPOLBCNR2 | |
| SCHEMBL11155819 | 0.72 | EPHX2 (0.40) | PTGER4RAB9ANPC1MAPTHPGD | |
| SCHEMBL9487727 | 0.72 | MAPT (0.50) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4388459-A | HYPOLIPIDEMIC, ANTIATHEROSCLEROTIC | AMERICAN CYANAMID COMPANY (US) | 1983-06-14 | — | — | US | disclosed |
| US-4259352-A | 4-[Cycloalkyl- or cycloalkenyl-amino(cycloalkyl- or cycloalkenyl-alkenyl)amino]phenyl compounds, useful as hypolipidemic and antiatherosclerotic agents | AMERICAN CYANAMID COMPANY (US) | 1981-03-31 | — | — | US | disclosed |