Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clonidine SCHEMBL1369066 | 0.87 | MAPT (0.34) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| Clonidine SCHEMBL5982 | 0.87 | MAPT (0.36) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| Clonidine SCHEMBL1369983 | 0.87 | MAPT (0.36) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| SCHEMBL4716982 | 0.87 | PARP10 (0.35) | PARP10PARP11 | |
| Clonidine SCHEMBL10972183 | 0.85 | ADRA2A (0.36) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| Clonidine SCHEMBL22127030 | 0.85 | MAPT (0.35) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| Clonidine SCHEMBL3974275 | 0.85 | ADRA2A (0.36) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| Clonidine SCHEMBL9838987 | 0.85 | MAPT (0.35) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| Clonidine SCHEMBL40751 | 0.85 | ADRA2A (0.36) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 | |
| Clonidine SCHEMBL1172959 | 0.85 | ADRA2A (0.36) | MAPTHSP90AA1MEN1SLC22A1SLC22A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007422-A1 | Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, medicaments containing them and processes for their preparation | C.H. BOEHRINGER SOHN (DE) | 1980-02-06 | — | — | EP | disclosed |