Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clonidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.33 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.33 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clonidine SCHEMBL1369983 | 0.98 | MAPT (0.36) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL5982 | 0.98 | MAPT (0.36) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL3974275 | 0.96 | ADRA2A (0.36) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL1172959 | 0.96 | ADRA2A (0.36) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL10972183 | 0.96 | ADRA2A (0.36) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL22127030 | 0.96 | MAPT (0.35) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL40751 | 0.96 | ADRA2A (0.36) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL22127029 | 0.94 | MAPT (0.34) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL1369066 | 0.94 | MAPT (0.34) | MAPTHSP90AA1ADRA2AADRA2CADRA1D | |
| Clonidine SCHEMBL27404261 | 0.92 | MAPT (0.37) | MAPTHSP90AA1ADRA2AADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220211672-A1 | METHODS OF TREATING PRURITUS | CLEXIO BIOSCIENCES LTD. (IL) | 2022-07-07 | — | — | US | disclosed |
| WO-2020222192-A1 | METHODS OF TREATING PRURITUS | CLEXIO BIOSCIENCES LTD. (IL) | 2020-11-05 | — | — | WO | disclosed |
| CN-101568544-B | Solid forms comprising 4- [9- (tetrahydro-furan-3-yl) -8- (2,4, 6-trifluoro-phenylamino) -9H-purin-2-ylamino ] -cyclohexan-1-ol, compositions thereof, and uses thereof | 西格诺药品有限公司 | 2016-10-26 | — | — | CN | disclosed |
| WO-1991001715-A1 | OPHTHALMIC COMPOSITIONS | SMITH & NEPHEW PLC (GB) | 1991-02-21 | — | — | WO | disclosed |