Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.42 |
| ▸ | HRH2 | P25021 | 6/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468247 | 1.00 | HRH4 (0.42) | HRH4HRH2HRH1HRH3MIF | |
| SCHEMBL7753802 | 0.83 | HRH4 (0.45) | HRH4HRH2HRH1HRH3 | |
| SCHEMBL7753798 | 0.83 | HRH4 (0.45) | HRH4HRH2HRH1HRH3 | |
| SCHEMBL11467208 | 0.82 | MIF (0.39) | HRH4HRH2HRH3MIF | |
| SCHEMBL11467205 | 0.81 | HRH4 (0.51) | HRH4HRH2HRH3MEN1CYP1A2 | |
| SCHEMBL11467207 | 0.81 | HRH4 (0.51) | HRH4HRH2HRH3MEN1CYP1A2 | |
| SCHEMBL11192767 | 0.74 | HRH4 (0.46) | HRH4HRH2HRH3MEN1CYP1A2 | |
| SCHEMBL9996188 | 0.71 | NAAA (0.46) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9996187 | 0.71 | NAAA (0.46) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7098788 | 0.70 | HRH4 (0.43) | HRH4HRH2HRH3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30457-E | HISTAMINE RECEPTOR ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-12-23 | — | — | US | disclosed |
| US-4152453-A | HISTAMINE RECEPTOR ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-01 | — | — | US | disclosed |