Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.45 |
| ▸ | HRH2 | P25021 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7753798 | 1.00 | HRH4 (0.45) | HRH4HRH2SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL11527427 | 0.83 | HRH4 (0.40) | HRH4HRH2SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL11527422 | 0.83 | GRIN2D (0.39) | HRH4HRH2SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL11527425 | 0.83 | GRIN2D (0.39) | HRH4HRH2SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL8165275 | 0.83 | SIGMAR1 (0.50) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11468245 | 0.83 | HRH4 (0.42) | HRH4HRH2HRH3HRH1 | |
| SCHEMBL11468247 | 0.83 | HRH4 (0.42) | HRH4HRH2HRH3HRH1 | |
| SCHEMBL7758085 | 0.81 | ALDH1A1 (0.46) | HRH4HRH3 | |
| SCHEMBL7758081 | 0.81 | ALDH1A1 (0.46) | HRH4HRH3 | |
| SCHEMBL7758091 | 0.81 | HRH4 (0.41) | HRH4HRH2SIGMAR1HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077933-A1 | SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2001-02-28 | — | — | EP | disclosed |
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |
| WO-1999058497-A1 | SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-11-18 | — | — | WO | disclosed |