Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | BCKDK | O14874 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19283514 | 0.87 | MCL1 (0.59) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| SCHEMBL9203348 | 0.84 | MCL1 (0.57) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| SCHEMBL5162517 | 0.80 | MCL1 (0.53) | MCL1RXFP1RAB9ANPC1MAPT | |
| SCHEMBL2723054 | 0.75 | BCKDK (0.75) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| SCHEMBL5228832 | 0.72 | BCKDK (0.61) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| SCHEMBL6886010 | 0.71 | MCL1 (1.00) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| SCHEMBL16862081 | 0.71 | BCKDK (0.56) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| SCHEMBL9204281 | 0.71 | MCL1 (0.56) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL11394582 | 0.70 | MCL1 (0.97) | MCL1RXFP1BCKDKRAB9ANPC1 | |
| SCHEMBL25735859 | 0.70 | MCL1 (0.73) | MCL1RXFP1BCKDKRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009142-A1 | 4-Hydroxy-2H(1)benzothieno(2,3-e)-1,2-thiazine-3-carboxamide-1,1-dioxide derivatives and salts thereof, their use and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1980-04-02 | — | — | EP | disclosed |