Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 4/20 | 0.40 |
| ▸ | CDK8 | P49336 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12984897 | 0.84 | PADI4 (0.49) | MAPTGSK3BAURKBINCENPCYP2C19 | |
| SCHEMBL7511441 | 0.75 | MAPT (0.58) | MAPTMAPK14GCGRGSK3BPDE3B | |
| SCHEMBL11449584 | 0.71 | MAPT (0.58) | MAPTMAPK14GCGRGSK3BPDE3B | |
| SCHEMBL2100160 | 0.71 | MAPT (0.58) | MAPTMAPK14GCGRGSK3BPDE3B | |
| Hydrochloric Acid SCHEMBL30730902 | 0.69 | MAPT (0.56) | MAPTMAPK14GCGRGSK3BPDE3B | |
| SCHEMBL11291385 | 0.69 | PDE3B (0.63) | MAPTGSK3BPDE3BPDE3AAURKB | |
| SCHEMBL17060505 | 0.68 | DAO (0.34) | MAPTAURKBINCENPKDM4ELMNA | |
| SCHEMBL14912178 | 0.68 | MAPT (0.54) | MAPTMAPK14GCGRGSK3BJAK2 | |
| SCHEMBL14912198 | 0.67 | MAPT (0.53) | MAPTMAPK14GCGRGSK3BAURKB | |
| SCHEMBL6535945 | 0.67 | MAPT (0.56) | MAPTPDE3BPDE3AJAK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225601-A | 3-Hydroxy or hydroxymethyl-5-(4-pyridinyl)2(1H)-pyridinones, useful as cardiotonic agents and their preparation | STERLING DRUG INC. (US) | 1980-09-30 | — | — | US | disclosed |