Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976914 | 0.89 | MAPT (0.63) | MAPTJAK2NOTUMPADI4FGFR1 | |
| SCHEMBL11468997 | 0.75 | MAPT (0.60) | MAPTJAK2PADI4MAPK14GSK3B | |
| SCHEMBL6936911 | 0.74 | CDC7 (0.54) | MAPTMAPK14GCGR | |
| SCHEMBL6936625 | 0.74 | CDC7 (0.54) | MAPTMAPK14GCGR | |
| SCHEMBL13203237 | 0.74 | NOTUM (0.61) | MAPTNOTUMGSK3BPIK3CDAURKA | |
| SCHEMBL1947214 | 0.74 | NOTUM (0.61) | MAPTNOTUMGSK3BPIK3CDAURKA | |
| SCHEMBL2100160 | 0.73 | MAPT (0.58) | MAPTMAPK14GSK3BPIK3CDGCGR | |
| Bromide SCHEMBL20502185 | 0.72 | NOTUM (0.58) | MAPTNOTUMGSK3BPIK3CDAURKA | |
| Hydrochloric Acid SCHEMBL30730902 | 0.72 | MAPT (0.56) | MAPTJAK2MAPK14GSK3BPIK3CD | |
| SCHEMBL14912178 | 0.70 | MAPT (0.54) | MAPTJAK2MAPK14GSK3BPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1328277-C | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2007-07-25 | — | — | CN | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| CN-1246857-A | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |