Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.34 |
| ▸ | MAOB | P27338 | 8/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25101381 | 0.74 | NPC1 (0.42) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL11469902 | 0.73 | NPC1 (0.36) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL19452371 | 0.73 | TSHR (0.36) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL13636753 | 0.73 | APP (0.41) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL779443 | 0.72 | NPC1 (0.58) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL13991702 | 0.71 | ALDH1A1 (0.47) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL11477380 | 0.70 | PTGS1 (0.36) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL11212275 | 0.70 | NPC1 (0.44) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL10365515 | 0.70 | AHR (0.45) | NPC1RAB9AMAPTLMNASMN1; SMN2 | |
| SCHEMBL846398 | 0.70 | ALDH1A1 (0.47) | NPC1RAB9AMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4202894-A | AGRICULTURE | HOFFMANN-LA ROCHE INC. (US) | 1980-05-13 | — | — | US | disclosed |