Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11471966 | 0.98 | NPC1 (0.43) | NPC1SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL546444 | 0.84 | NPC1 (0.56) | NPC1HPGDNAAAEPHX1 | |
| SCHEMBL12073502 | 0.83 | NPC1 (0.39) | NPC1SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL87084 | 0.81 | SLC6A4 (0.36) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL10357183 | 0.81 | NPC1 (0.61) | NPC1HPGDNAAAEPHX1 | |
| SCHEMBL6376493 | 0.81 | NPC1 (0.61) | NPC1HPGDNAAAEPHX1 | |
| SCHEMBL6377426 | 0.81 | NPC1 (0.61) | NPC1HPGDNAAAEPHX1 | |
| SCHEMBL27888489 | 0.81 | NPC1 (0.54) | NPC1SLC6A2SLC6A4SLC6A3HPGD | |
| SCHEMBL6383859 | 0.81 | NPC1 (0.61) | NPC1HPGDNAAAEPHX1 | |
| SCHEMBL6379525 | 0.81 | NPC1 (0.61) | NPC1HPGDNAAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4237138-A | REGULATORS OF CARDIOVASCULAR SYSTEM | PFIZER INC. (US) | 1980-12-02 | — | — | US | disclosed |