Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6400925 | 0.80 | PDE3B (0.56) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL13400655 | 0.77 | ALDH1A1 (0.41) | GPR119KDM4EKMT2AGAAMEN1 | |
| SCHEMBL13400652 | 0.77 | ALDH1A1 (0.41) | GPR119KDM4EKMT2AGAAMEN1 | |
| SCHEMBL2591981 | 0.76 | GPR119 (1.00) | GPR119 | |
| SCHEMBL2592363 | 0.76 | GPR119 (1.00) | GPR119 | |
| SCHEMBL7305470 | 0.76 | KDM4E (0.41) | GPR119KDM4EKMT2AGAAMEN1 | |
| SCHEMBL10814317 | 0.74 | GPR119 (0.59) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL8110180 | 0.73 | PDE3B (0.48) | GPR119PDE3BPDE3APDE4APDE4B | |
| SCHEMBL11092220 | 0.73 | GPR119 (0.60) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11369154 | 0.73 | GPR119 (0.60) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4230705-A | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety | AMERICAN CYANAMID COMPANY (US) | 1980-10-28 | — | — | US | disclosed |