Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 5/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11478334 | 0.90 | SETD7 (0.50) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL11456307 | 0.86 | SETD7 (0.68) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL11471188 | 0.85 | SETD7 (0.47) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL11478221 | 0.76 | SETD7 (0.69) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL11459013 | 0.76 | SETD7 (0.48) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL11474273 | 0.75 | SETD7 (0.49) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL12683270 | 0.71 | DRD2 (0.50) | DRD1DRD3DRD2CHKA | |
| SCHEMBL14087482 | 0.71 | SETD7 (0.74) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL11753249 | 0.69 | SETD7 (0.55) | SETD7CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL3789710 | 0.69 | MAPK1 (0.60) | SETD7CHRM2HTR1ACHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015458-A1 | 3-Hydroxymethylcyproheptadine and analogs, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1980-09-17 | — | — | EP | disclosed |
| US-4212871-A | Appetite stimulating and antihistaminic 3-hydroxymethylcyproheptadine and analogs | MERCK & CO., INC. (US) | 1980-07-15 | — | — | US | disclosed |