Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 7/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11472216 | 0.90 | SETD7 (0.48) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11478221 | 0.87 | SETD7 (0.69) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11474273 | 0.86 | SETD7 (0.49) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11753249 | 0.81 | SETD7 (0.55) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11464514 | 0.77 | SETD7 (0.50) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11456307 | 0.76 | SETD7 (0.68) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11471188 | 0.75 | SETD7 (0.47) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL9444000 | 0.74 | SETD7 (0.69) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11751306 | 0.74 | SETD7 (0.47) | SETD7CHRM2HTR1AADRA2ACYP2D6 | |
| SCHEMBL11601000 | 0.69 | SETD7 (0.53) | SETD7CHRM2HTR1AADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015458-A1 | 3-Hydroxymethylcyproheptadine and analogs, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1980-09-17 | — | — | EP | disclosed |
| US-4212871-A | Appetite stimulating and antihistaminic 3-hydroxymethylcyproheptadine and analogs | MERCK & CO., INC. (US) | 1980-07-15 | — | — | US | disclosed |