Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 17/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18197243 | 0.86 | GAA (0.43) | GAAIGF1RRORC | |
| SCHEMBL431492 | 0.80 | TRPV1 (0.41) | IGF1R | |
| SCHEMBL30358011 | 0.80 | IGF1R (0.46) | IGF1R | |
| SCHEMBL11472931 | 0.78 | AR (0.42) | GAARORCNR1H3NR1H2NR1I2 | |
| SCHEMBL30358050 | 0.77 | IGF1R (0.46) | IGF1R | |
| SCHEMBL3893061 | 0.77 | IGF1R (0.46) | IGF1R | |
| SCHEMBL30357998 | 0.77 | IGF1R (0.46) | IGF1R | |
| SCHEMBL7335768 | 0.77 | ALDH1A1 (0.51) | IGF1R | |
| SCHEMBL30358032 | 0.77 | ALDH1A1 (0.51) | IGF1R | |
| SCHEMBL7433964 | 0.74 | SMYD3 (0.56) | GAAIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663469-B2 | RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663469-B2 | RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160318870-A1 | RORy MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-11-03 | — | — | US | disclosed |
| WO-2015035278-A1 | RORγ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318870-A1 | RORy MODULATORS | RORB, RORC, RORA | GAA 2554/4885IGF1R 2843/4885RORC 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.