Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 12/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11578289 | 1.00 | CNR2 (0.62) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL11578292 | 1.00 | CNR2 (0.62) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL11501223 | 0.88 | CNR1 (0.59) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL10068290 | 0.87 | CNR2 (0.69) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL11608910 | 0.86 | CNR2 (0.63) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL17686850 | 0.84 | CNR2 (0.71) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL7755404 | 0.82 | CNR2 (0.72) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL11455743 | 0.82 | CNR2 (0.72) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL11541884 | 0.82 | CNR2 (0.72) | CNR2NR1I2ADORA3CNR1SLC6A3 | |
| SCHEMBL15558108 | 0.82 | CNR2 (0.72) | CNR2NR1I2ADORA3CNR1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4278603-A | SEDATIVES, ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1981-07-14 | — | — | US | disclosed |
| US-4133816-A | Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |
| US-4115403-A | Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo [b,d]pyran-9-ones and intermediates therefor | ELI LILLY AND COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4088777-A | Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs | ELI LILLY AND COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4087547-A | Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087546-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087545-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4054581-A | Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor | ELI LILLY AND COMPANY (US) | 1977-10-18 | — | — | US | disclosed |
| US-3987188-A | Hexahydro-dibenzo[b,d]pyran-9-ones as sedative drugs | ELI LILLY AND COMPANY (US) | 1976-10-19 | — | — | US | disclosed |