Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11487769 | 0.99 | OPRM1 (0.51) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL11476409 | 0.85 | SLC18A3 (0.41) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL11487147 | 0.85 | OPRL1 (0.42) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| Bromide SCHEMBL11481829 | 0.84 | KCNA3 (0.59) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Oxalic Acid SCHEMBL11490183 | 0.84 | KDM4E (0.40) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| Oxalic Acid SCHEMBL11486149 | 0.83 | SMN1; SMN2 (0.42) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL11477351 | 0.83 | OPRM1 (0.51) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL11487820 | 0.83 | KCNA3 (0.60) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Oxalic Acid SCHEMBL11483278 | 0.81 | OPRM1 (0.49) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Bromide SCHEMBL11472634 | 0.81 | OPRM1 (0.51) | OPRM1OPRD1OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |