Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.49 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | FERMT2 | Q96AC1 | 3/20 | 0.45 |
| ▸ | PRNP | P04156 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147545 | 0.95 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL1147354 | 0.94 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL1147357 | 0.94 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL1147530 | 0.92 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL28641515 | 0.85 | CDK1 (0.52) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL28900632 | 0.84 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL13481253 | 0.83 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL4150418 | 0.82 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL12631853 | 0.82 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1GLAMAPT | |
| SCHEMBL7502330 | 0.81 | NR4A2 (0.51) | LMNASMN1; SMN2ALDH1A1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110045100-A1 | Antimalarial Quinolines and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110045100-A1 | Antimalarial Quinolines and Methods of Use Thereof | NQO2, QTRT1, QTRT2 | LMNA 2030/4885SMN1; SMN2 3341/4885ALDH1A1 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.