Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluvastatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 7/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.98 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.98 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.98 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.98 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.98 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | RXRA | P19793 | 1/20 | 0.98 |
| ▸ | CCKAR | P32238 | 1/20 | 0.98 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.98 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluvastatin SCHEMBL6250394 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL4620256 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL1147653 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL41662 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL41664 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL5072556 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL344982 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL6270543 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL246750 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D | |
| Fluvastatin SCHEMBL28166565 | 1.00 | HMGCR (0.98) | HMGCRCYP2C9SIRT6NR4A2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4681808-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| US-7432380-B2 | Crystalline form of Fluvastatin sodium | CIBA SPECIALTY CHEMICALS CORP. (US) | 2008-10-07 | — | — | US | claimed |
| EP-1429757-B8 | CRYSTALLINE FORMS OF FLUVASTATIN SODIUM | CIBA HOLDING INC (CH) | 2008-07-16 | — | — | EP | claimed |
| EP-1429757-B1 | CRYSTALLINE FORMS OF FLUVASTATIN SODIUM | CIBA SC HOLDING AG (CH) | 2008-04-09 | — | — | EP | claimed |
| US-20060241167-A1 | Crystalline form of fluvastatin sodium | CIBA SPECIALTY CHEMICALS CORP. | 2006-10-26 | — | — | US | claimed |
| WO-2005037787-A1 | CRYSTALLINE FORM OF FLUVASTATIN SODIUM | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2005-04-28 | — | — | WO | claimed |
| WO-2005019170-A1 | NOVEL PROCESS FOR PREPARATION OF 7-[3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOL-2-YL]-3, 5-DIHYDROXY-6-HEPTENOIC ACID SODIUM SALT | BIOCON LIMITED (IN) | 2005-03-03 | — | — | WO | claimed |
| EP-1429757-A2 | CRYSTALLINE FORMS OF FLUVASTATIN SODIUM | Ciba SC Holding AG (CH) | 2004-06-23 | — | — | EP | claimed |
| US-6696479-B2 | HIGHLY CRYSTALLINE FLUVASTATIN SODIUM FORM A | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-02-24 | — | — | US | claimed |
| WO-2003013512-A2 | CRYSTALLINE FORMS OF FLUVASTATIN SODIUM | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2003-02-20 | — | — | WO | claimed |
| US-20030032666-A1 | Crystalline forms | CIBA SPECIALTY CHEMICALS CORP. | 2003-02-13 | — | — | US | claimed |
| CN-102805739-B | Fluvastatin sodium sustained-release coated dropping pills and preparation method thereof | SONG YUN | 2013-08-14 | — | — | CN | disclosed |
| CN-102805739-A | Fluvastatin sodium sustained-release coated dropping pills and preparation method thereof | SONG YUN | 2012-12-05 | — | — | CN | disclosed |
| US-20110046396-A1 | POLYMORPHIC FORMS OF FLUVASTATIN SODIUM AND PROCESS FOR PREPARING THE SAME | JUBILANT ORGANOSYS LIMITED (IN) | 2011-02-24 | — | — | US | disclosed |
| US-7795451-B2 | Polymorphic forms of fluvastatin sodium and process for preparing the same | JUBILANT ORGANOSYS LIMITED (IN) | 2010-09-14 | — | — | US | disclosed |
| EP-1330435-A1 | CRYSTALLINE FORMS OF FLUVASTATIN SODIUM | Ciba SC Holding AG (CH) | 2003-07-30 | — | — | EP | disclosed |
| US-20030125569-A1 | Use of packing strip as a holographic data carrier | CIBA SPECIALTY CHEMICALS CORP. | 2003-07-03 | — | — | US | disclosed |
| WO-2003013512-A2 | CRYSTALLINE FORMS OF FLUVASTATIN SODIUM | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2003-02-20 | — | — | WO | disclosed |
| US-20030032666-A1 | Crystalline forms | CIBA SPECIALTY CHEMICALS CORP. | 2003-02-13 | — | — | US | disclosed |
| WO-2002036563-A1 | CRYSTALLINE FORMS OF FLUVASTATIN SODIUM | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241167-A1 | Crystalline form of fluvastatin sodium | HMGCR, CYP4A11, CYP4F11 | HMGCR 1/4885CYP2C9 21/4885SIRT6 1461/4885 |
| US-20030032666-A1 | Crystalline forms | HMGCR, CYP4F3, CYP2F1 | HMGCR 1/4885CYP2C9 35/4885SIRT6 1336/4885 |
| US-20030125569-A1 | Use of packing strip as a holographic data carrier | HMGCR, HSD3B1, HSD3B2 | HMGCR 1/4885CYP2C9 17/4885SIRT6 3064/4885 |
| US-20110046396-A1 | POLYMORPHIC FORMS OF FLUVASTATIN SODIUM AND PROCESS FOR PREPARING THE SAME | CYP4F3, CYP2F1, CYP3A43 | HMGCR 19/4885CYP2C9 39/4885SIRT6 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.