Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11477639 | 1.00 | TRPM8 (0.50) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11508798 | 0.96 | TRPM8 (0.48) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11508799 | 0.96 | TRPM8 (0.48) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11500743 | 0.84 | TRPM8 (0.46) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11579712 | 0.80 | TRPM8 (0.44) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11546924 | 0.76 | MEN1 (0.47) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11472081 | 0.75 | TRPM8 (0.46) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11472079 | 0.75 | TRPM8 (0.46) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11472080 | 0.75 | LMNA (0.38) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11446742 | 0.72 | MEN1 (0.45) | TRPM8ALDH1A1SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |