Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11411479 | 0.89 | MAPT (0.58) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11465002 | 0.89 | TNKS (0.58) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11471226 | 0.89 | KDM4E (0.58) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11463568 | 0.89 | MAPT (0.58) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11461259 | 0.89 | MAPK8 (0.56) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11467626 | 0.86 | KMT2A (0.61) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11460081 | 0.86 | MAPK8 (0.59) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11463548 | 0.83 | KMT2A (0.69) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11462148 | 0.83 | KMT2A (0.56) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 | |
| SCHEMBL11469700 | 0.83 | ABCG2 (0.51) | MAPK8SMN1; SMN2LMNAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205602-B1 | IMIDAZO[1,2-A]QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS | UNIV MONTPELLIER (FR) | 2018-09-26 | — | — | EP | disclosed |
| WO-2017037604-A1 | NOVEL FYN KINASE INHIBITORS | PARASELLI BHEEMA RAO (US) | 2017-03-09 | — | — | WO | disclosed |
| US-4191766-A | 4-(SUBSTITUTED PHENYL OR ANILINO)IMIDAZO(1,2-A)QUINOXALINES | WESTWOOD PHARMACEUTICALS, INC. (US) | 1980-03-04 | — | — | US | disclosed |