Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11494495 | 0.83 | NPC1 (0.49) | NPC1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL7678041 | 0.80 | CXCL8 (0.72) | PTGS1CXCL8AKR1B1PTGS2GLO1 | |
| SCHEMBL8732029 | 0.77 | PTGS1 (0.67) | PTGS1CXCL8AKR1B1PTGS2GLO1 | |
| SCHEMBL7685205 | 0.77 | CXCL8 (0.63) | PTGS1CXCL8AKR1B1PTGS2GLO1 | |
| SCHEMBL7682135 | 0.77 | CXCL8 (0.59) | PTGS1CXCL8AKR1B1PTGS2GLO1 | |
| SCHEMBL8732318 | 0.76 | CXCL8 (0.51) | PTGS1CXCL8AKR1B1PTGS2GLO1 | |
| SCHEMBL31575666 | 0.74 | NPC1 (0.79) | NPC1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL285924 | 0.74 | NPC1 (0.79) | NPC1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL25410220 | 0.74 | NPC1 (0.73) | NPC1PTGS1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL8732079 | 0.72 | CXCL8 (0.50) | NPC1PTGS1CXCL8AKR1B1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4213905-A | Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid salts | MCNEILAB, INC. (US) | 1980-07-22 | — | — | US | disclosed |