Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489245 | 0.92 | ALDH1A1 (0.56) | ALDH1A1OPRM1OPRD1HPGDCD274 | |
| SCHEMBL11496100 | 0.88 | ALDH1A1 (0.60) | ALDH1A1OPRM1OPRD1CD274SLC6A4 | |
| SCHEMBL11492547 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CD274MEN1KMT2ATP53 | |
| SCHEMBL11486569 | 0.88 | ALDH1A1 (0.63) | ALDH1A1OPRM1OPRD1CD274MEN1 | |
| SCHEMBL11495457 | 0.88 | ALDH1A1 (0.60) | ALDH1A1OPRM1OPRD1HPGDCD274 | |
| SCHEMBL11489480 | 0.87 | CYP2D6 (0.56) | OPRM1SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL11494367 | 0.86 | MEN1 (0.48) | ALDH1A1HPGDCD274MEN1KMT2A | |
| SCHEMBL11494398 | 0.86 | SLC6A4 (0.56) | ALDH1A1SLC6A4SLC6A3NPC1RAB9A | |
| SCHEMBL11487380 | 0.86 | CYP2D6 (0.59) | OPRM1SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL11495695 | 0.85 | ALDH1A1 (0.68) | ALDH1A1OPRM1OPRD1HPGDSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |