Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11492188 | 0.87 | CD274 (0.49) | CD274CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11496251 | 0.87 | KMT2A (0.50) | MEN1KMT2ACD274NPC1RAB9A | |
| SCHEMBL11495715 | 0.87 | ALDH1A1 (0.52) | MEN1KMT2ACD274LMNANPC1 | |
| SCHEMBL11486715 | 0.86 | ALDH1A1 (0.62) | MEN1KMT2AHPGDCD274LMNA | |
| SCHEMBL11488903 | 0.85 | CYP2D6 (0.46) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL11489245 | 0.83 | ALDH1A1 (0.56) | MEN1KMT2AHPGDCD274LMNA | |
| SCHEMBL11494370 | 0.80 | SMN1; SMN2 (0.46) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11487591 | 0.75 | ALDH1A1 (0.50) | MEN1KMT2AHPGDLMNASMN1; SMN2 | |
| SCHEMBL14354524 | 0.74 | CHRM2 (0.56) | MEN1KMT2ACYP2D6LMNAALDH1A1 | |
| SCHEMBL11496100 | 0.73 | ALDH1A1 (0.60) | MEN1KMT2ACD274LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |