Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.40 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11483187 | 0.97 | SMN1; SMN2 (0.46) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| Oxalic Acid SCHEMBL11490159 | 0.86 | KDM4E (0.47) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| Oxalic Acid SCHEMBL11476695 | 0.84 | KDM4E (0.46) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| SCHEMBL11477977 | 0.84 | SMN1; SMN2 (0.46) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| SCHEMBL11481965 | 0.84 | OPRM1 (0.48) | KDM4ESMN1; SMN2ALDH1A1TDP1CHRNA7 | |
| Oxalic Acid SCHEMBL11486149 | 0.83 | SMN1; SMN2 (0.42) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| Bromide SCHEMBL11487097 | 0.82 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| SCHEMBL11478460 | 0.82 | USP30 (0.38) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| SCHEMBL11482078 | 0.81 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| SCHEMBL11477972 | 0.80 | HTR1A (0.41) | SMN1; SMN2ALDH1A1TDP1MAPTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |