Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.50 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489183 | 0.99 | LTA4H (0.55) | LTA4HPTGS2ALDH1A1PSMB1PSMB5 | |
| SCHEMBL11493248 | 0.99 | LTA4H (0.55) | LTA4HPTGS2ALDH1A1PSMB1PSMB5 | |
| SCHEMBL11489481 | 0.90 | ALDH1A1 (0.49) | LTA4HPTGS2ALDH1A1PSMB1PSMB5 | |
| SCHEMBL11487333 | 0.88 | ALDH1A1 (0.67) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL11489338 | 0.88 | LTA4H (0.55) | LTA4HALDH1A1PSMB1PSMB5PSMB2 | |
| SCHEMBL11496495 | 0.87 | ALDH1A1 (0.47) | ALDH1A1PSMB1PSMB5PSMB2LMNA | |
| SCHEMBL11494283 | 0.87 | KDM4E (0.53) | ALDH1A1HRH3MEN1KMT2AKDM4E | |
| SCHEMBL11496144 | 0.87 | ALDH1A1 (0.45) | LTA4HPTGS2ALDH1A1PSMB1PSMB5 | |
| SCHEMBL11487323 | 0.86 | LTA4H (0.56) | LTA4HPTGS2ALDH1A1PSMB1PSMB5 | |
| SCHEMBL11495711 | 0.86 | ALDH1A1 (0.55) | LTA4HALDH1A1PSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |