Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11488794 | 1.00 | JAK2 (0.46) | JAK2JAK3RXFP1GCGRKDM4E | |
| SCHEMBL11487263 | 0.86 | JAK2 (0.46) | JAK2JAK3RXFP1GCGRKDM4E | |
| SCHEMBL11486278 | 0.85 | NOTUM (0.45) | JAK2JAK3RXFP1GCGRKDM4E | |
| SCHEMBL11492862 | 0.80 | MAPK1 (0.50) | GCGRKDM4EALDH1A1MAPK1NOTUM | |
| SCHEMBL11492867 | 0.80 | MAPK1 (0.50) | GCGRKDM4EALDH1A1MAPK1NOTUM | |
| SCHEMBL7670225 | 0.79 | LMNA (0.51) | JAK2JAK3RXFP1GCGRKDM4E | |
| SCHEMBL1363765 | 0.79 | RXFP1 (0.61) | JAK2JAK3RXFP1KDM4EALDH1A1 | |
| SCHEMBL11438726 | 0.79 | ALDH1A1 (0.60) | ALDH1A1POLBMEN1KMT2AMAPT | |
| SCHEMBL3944862 | 0.77 | PPARG (0.53) | JAK2JAK3RXFP1KDM4EALDH1A1 | |
| SCHEMBL2570519 | 0.76 | JAK2 (0.42) | JAK2JAK3RXFP1GCGRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239901-A | ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1980-12-16 | — | — | US | disclosed |